SCHEMBL25919448

SCHEMBL25919448

Fc1cc(C#Cc2ccc(C3CCCCC3)cc2)cc(F)c1N=C=S

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.34
CYP2C9 P11712 1/20 0.34
P2RY14 Q15391 1/20 0.33
APP P05067 1/20 0.32
KCNH2 Q12809 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32
DEGS1 O15121 1/20 0.32
HSP90AA1 P07900 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21577536 0.91 P2RY14 (0.31) P2RY14
SCHEMBL21577530 0.89 P2RY14 (0.33) P2RY14
SCHEMBL21577531 0.88 P2RY14 (0.31) P2RY14
SCHEMBL21577535 0.87 HDAC2 (0.33) P2RY14
SCHEMBL21577526 0.87 ESR2 (0.42) P2RY14
SCHEMBL21577529 0.86 ESR2 (0.38) CYP3A4CYP2C9P2RY14MAPTKMT2A
SCHEMBL21577534 0.86 ESR2 (0.33) CYP3A4CYP2C9P2RY14
SCHEMBL23510914 0.84 P2RY14 (0.32) P2RY14
SCHEMBL21577521 0.84 ESR2 (0.32) CYP3A4CYP2C9P2RY14MAPTKMT2A
SCHEMBL21577524 0.84 P2RY14 (0.30) P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230235228-A1 LIQUID CRYSTAL (LC) COMPOSITION WITH EXTREMELY-LOW DIELECTRIC LOSS AND HIGH-FREQUENCY COMPONENT INCLUDING SAME XI'AN MODERN CHEMISTRY RESEARCH INSTITUTE (CN) 2023-07-27 US disclosed