Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 8/20 | 0.37 |
| ▸ | GSK3B | P49841 | 7/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21310845 | 0.97 | HCAR1 (0.50) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL21310840 | 0.89 | HCAR1 (0.37) | HCAR1ALDH1A1CYP2A6CYP11B2CYP11B1 | |
| SCHEMBL17583061 | 0.79 | HCAR1 (0.45) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL17582727 | 0.79 | CYP11B1 (0.49) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL21310850 | 0.79 | KDM4E (0.37) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL21310848 | 0.78 | KDM4E (0.38) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL21310847 | 0.78 | KDM4E (0.38) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL14247637 | 0.77 | HCAR1 (0.48) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL2362323 | 0.77 | CYP11B2 (0.50) | HCAR1ALDH1A1KDM4EMAPTGFER | |
| SCHEMBL17583042 | 0.76 | CYP11B2 (0.52) | HCAR1PRKACACDK9DYRK1ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3572405-B1 | BENZOIMIDAZOL-1,2-YL AMIDES AS KV7 CHANNEL ACTIVATORS | KNOPP BIOSCIENCES LLC (US) | 2023-07-26 | — | — | EP | disclosed |