Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919156 | 0.87 | OPRD1 (0.39) | OPRM1OPRD1KCNH2CYP2D6OPRK1 | |
| SCHEMBL2592448 | 0.85 | OPRD1 (0.37) | OPRM1OPRD1KCNH2CYP2D6OPRK1 | |
| SCHEMBL14919240 | 0.81 | OPRD1 (0.35) | OPRM1OPRD1KCNH2CYP2D6OPRK1 | |
| SCHEMBL2586790 | 0.80 | DDB1 (0.41) | OPRM1DDB1CRBNOPRD1KCNH2 | |
| SCHEMBL22014537 | 0.67 | OPRM1 (0.51) | OPRM1DDB1CRBN | |
| SCHEMBL13339986 | 0.67 | OPRD1 (0.43) | OPRM1OPRD1KCNH2CYP2D6OPRK1 | |
| SCHEMBL5213485 | 0.67 | DDB1 (0.51) | OPRM1DDB1CRBN | |
| SCHEMBL2586824 | 0.67 | OPRD1 (0.44) | OPRM1OPRD1KCNH2CYP2D6OPRK1 | |
| SCHEMBL2594953 | 0.67 | GAA (0.43) | OPRM1DDB1CRBNOPRD1KCNH2 | |
| SCHEMBL2592703 | 0.67 | OPRD1 (0.36) | OPRM1OPRD1KCNH2CYP2D6OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |