Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555085 | 0.78 | MAPK8 (0.66) | MAPTADORA2BSLC9A1 | |
| SCHEMBL17825072 | 0.76 | PARG (0.60) | SLC9A1 | |
| SCHEMBL6363131 | 0.76 | MAPK8 (0.64) | TSHRKMT2AHTTALDH1A1HSD17B10 | |
| SCHEMBL17241694 | 0.75 | TSHR (0.85) | TSHRMEN1KMT2APOLBHTT | |
| SCHEMBL17241596 | 0.74 | TSHR (0.62) | TSHRMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL6509732 | 0.74 | MEN1 (0.60) | TSHRMEN1KMT2AMAPTTHRB | |
| SCHEMBL5039317 | 0.74 | ERCC1 (0.57) | TSHRHTTALDH1A1HSD17B10KDM4E | |
| SCHEMBL11884498 | 0.74 | ERCC1 (0.62) | TSHRHTTALDH1A1HSD17B10KDM4E | |
| SCHEMBL9392263 | 0.74 | MAPK1 (0.58) | MEN1KMT2APOLBNPSR1GLA | |
| SCHEMBL14692425 | 0.73 | ERCC1 (0.56) | TSHRHTTALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10653676-B2 | Small molecule inhibitors of USP1 deubiquitinating enzyme activity | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-20170202810-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-07-20 | — | — | US | disclosed |
| US-9518032-B2 | Small molecule inhibitors of USP1 deubiquitinating enzyme activity | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-13 | — | — | US | disclosed |
| US-20130253005-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| WO-2011137320-A2 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130253005-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | USP1, USP2, USP28 | TSHR 4060/4885MEN1 2034/4885KMT2A 639/4885 |
| US-10653676-B2 | Small molecule inhibitors of USP1 deubiquitinating enzyme activity | USP1, USP2, USP28 | TSHR 4060/4885MEN1 2034/4885KMT2A 639/4885 |
| US-20170202810-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | USP1, USP2, USP28 | TSHR 4060/4885MEN1 2034/4885KMT2A 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.