Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25930075 | 0.80 | EGFR (0.35) | EGFRFGFR1FGFR2FGFR3MAP3K7 | |
| SCHEMBL25925229 | 0.79 | EGFR (0.39) | EGFRMAP3K7TAB1MAP4K1 | |
| SCHEMBL25932088 | 0.78 | PIK3CD (0.38) | EGFRFGFR1FGFR2FGFR3 | |
| SCHEMBL25922675 | 0.78 | MAPK1 (0.43) | EGFRFGFR1FGFR2FGFR3IRAK4 | |
| SCHEMBL25926617 | 0.76 | JAK2 (0.36) | EGFRFGFR1FGFR2FGFR3MAP3K7 | |
| SCHEMBL25927872 | 0.76 | JAK2 (0.38) | EGFRMAP3K7TAB1IRAK4BRD4 | |
| SCHEMBL25931226 | 0.75 | LRRK2 (0.35) | EGFRMAP3K7TAB1IRAK4BRD4 | |
| SCHEMBL25929255 | 0.74 | EGFR (0.36) | EGFRMAP3K7TAB1BRD4 | |
| SCHEMBL25932661 | 0.74 | ABL1 (0.38) | EGFRMAP3K7TAB1MAP4K1 | |
| SCHEMBL25932040 | 0.73 | MCHR1 (0.40) | EGFRFGFR1FGFR2FGFR3MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |