Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 6/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25924724 | 0.91 | MET (0.38) | EGFRMAP3K7TAB1JAK1MET | |
| SCHEMBL25924720 | 0.88 | CYP1A2 (0.48) | MAP3K7TAB1METMAP4K1 | |
| SCHEMBL25924718 | 0.85 | TNK2 (0.49) | EGFRMAP3K7TAB1METHTR6 | |
| SCHEMBL2283400 | 0.85 | PDPK1 (0.42) | HTR6WNT1GSK3BDYRK1ACDK2 | |
| SCHEMBL24723287 | 0.82 | CYP3A4 (0.46) | EGFRACVR1MAP3K7TAB1JAK1 | |
| SCHEMBL29273533 | 0.80 | BMPR1A (0.42) | EGFRACVR1BMPR1AACVRL1MAP3K7 | |
| SCHEMBL25926294 | 0.79 | EGFR (0.37) | EGFRMAP3K7TAB1MAP4K1 | |
| SCHEMBL24722970 | 0.79 | JAK1 (0.39) | EGFRACVR1BMPR1AACVRL1MAP3K7 | |
| SCHEMBL25925739 | 0.78 | MET (0.37) | EGFRMAP3K7TAB1JAK1MET | |
| SCHEMBL25924810 | 0.77 | MET (0.40) | MAP3K7TAB1JAK1METHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |