Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nifurthiazole SCHEMBL194337 | 0.87 | HSP90AA1 (0.45) | HSP90AA1NPC1MEN1KMT2AMAPT | |
| SCHEMBL29376467 | 0.80 | NPC1 (0.47) | HSP90AA1NPC1MEN1KMT2AMAPT | |
| SCHEMBL3824030 | 0.79 | RAB9A (0.62) | HSP90AA1NPC1MEN1KMT2AMAPT | |
| SCHEMBL18588878 | 0.77 | MAPT (0.53) | HSP90AA1NPC1MEN1KMT2AMAPT | |
| SCHEMBL3344653 | 0.77 | MAPT (0.53) | HSP90AA1NPC1MEN1KMT2AMAPT | |
| SCHEMBL29500370 | 0.70 | MAPT (0.57) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL11827105 | 0.69 | NPC1 (0.49) | HSP90AA1NPC1MEN1KMT2AMAPT | |
| SCHEMBL11827112 | 0.69 | NPC1 (0.49) | HSP90AA1NPC1MEN1KMT2AMAPT | |
| SCHEMBL4503044 | 0.67 | MEN1 (0.60) | NPC1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL5901944 | 0.66 | SLC2A1 (0.42) | HSP90AA1NPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257125-A1 | HIGH-AFFINITY, ISOFORM-SELECTIVE TGFß1 INHIBITORS AND USE THEREOF | SCHOLAR ROCK INC (US) | 2025-08-14 | — | — | US | disclosed |
| US-20250215072-A1 | ISOFORM-SELECTIVE TGFB1 INHIBITORS AND USE THEREOF | SCHOLAR ROCK, INC. | 2025-07-03 | — | — | US | disclosed |
| WO-2025078478-A1 | CANDIDA AFRICANA FOR USE IN THE TREATMENT OF CANCER | AB MAURI (UK) LTD (GB) | 2025-04-17 | — | — | WO | disclosed |
| US-12252531-B2 | Methods of screening for high-affinity, isoform-selective TGFβ1 inhibitors | SCHOLAR ROCK, INC. (US) | 2025-03-18 | — | — | US | disclosed |
| US-12122823-B2 | Isoform-selective TGFB1 inhibitors and use thereof | SCHOLAR ROCK, INC. (US) | 2024-10-22 | — | — | US | disclosed |
| US-20230092707-A1 | METHODS FOR TREATING CANCER OR INFECTION USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY, AN ANTI-CTLA4 ANTIBODY, AND AN ANTI-TIGIT ANTIBODY | MERCK SHARP & DOHME LLC (US) | 2023-03-23 | — | — | US | disclosed |
| US-20230057012-A1 | TGFB INHIBITORS AND USE THEREOF | SCHOLAR ROCK, INC. | 2023-02-23 | — | — | US | disclosed |
| US-20230050148-A1 | TGF-BETA INHIBITORS AND USE THEREOF | SCHOLAR ROCK, INC. | 2023-02-16 | — | — | US | disclosed |
| EP-4114863-A1 | METHODS FOR TREATING CANCER OR INFECTION USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY, AN ANTI-CTLA4 ANTIBODY, AND AN ANTI-TIGIT ANTIBODY | Merck Sharp & Dohme LLC (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-4087659-A2 | TGF-BETA INHIBITORS AND USE THEREOF | Scholar Rock, Inc. (US) | 2022-11-16 | — | — | EP | disclosed |
| US-4877872-A | DETECTING AND TREATING TUMORS | THE UNIVERSITY OF TOLEDO (US) | 1989-10-31 | — | — | US | disclosed |
| EP-0256036-A1 | PRODUCTION AND USE OF PURPURINS, CHLORINS AND PURPURIN- AND CHLORIN-CONTAINING COMPOSITIONS. | UNIV TOLEDO (US) | 1988-02-24 | — | — | EP | disclosed |
| WO-1987004071-A1 | PRODUCTION AND USE OF PURPURINS, CHLORINS AND PURPURIN- AND CHLORIN-CONTAINING COMPOSITIONS | THE UNIVERSITY OF TOLEDO (US) | 1987-07-16 | — | — | WO | disclosed |
| US-4640912-A | IRRIGATION SURFACES WITH AQUEOUS SOLUTION | BIOMED RESEARCH, INC. | 1987-02-03 | — | — | US | disclosed |
| EP-0027133-B1 | AN IN VITRO METHOD FOR DETERMINING MALIGNANCY IN MAMMALIAN TISSUE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1985-02-20 | — | — | EP | disclosed |
| US-4334017-A | Method for detecting cancer in mammalian tissue | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1982-06-08 | — | — | US | disclosed |
| EP-0027133-A4 | AN IN VITRO METHOD FOR DETERMINING MALIGNANCY IN MAMMALIAN TISSUE. | MASSACHUSETTS INST TECHNOLOGY (US) | 1981-08-27 | — | — | EP | disclosed |
| EP-0027133-A1 | AN IN VITRO METHOD FOR DETERMINING MALIGNANCY IN MAMMALIAN TISSUE. | MASSACHUSETTS INST TECHNOLOGY (US) | 1981-04-22 | — | — | EP | disclosed |
| WO-1980002296-A1 | ENZYMATIC METHOD FOR DETECTING CANCER IN MAMMALIAN TISSUE | MASSACHUSETTS INST TECHNOLOGY (US) | 1980-10-30 | — | — | WO | disclosed |
| US-4132600-A | MEASURING LEVEL OF GALACTOSYL TRANSFERASE ACTIVITY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1979-01-02 | — | — | US | disclosed |