Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.81 |
| ▸ | MET | P08581 | 9/20 | 0.81 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.81 |
| ▸ | TEK | Q02763 | 2/20 | 0.81 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.81 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.81 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.52 |
| ▸ | MST1R | Q04912 | 2/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | HCK | P08631 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138653 | 0.90 | KDR (0.77) | KDRMETNTRK1TEKNTRK2 | |
| Altiratinib SCHEMBL30337737 | 0.90 | KDR (1.00) | KDRMETNTRK1TEKNTRK2 | |
| Altiratinib SCHEMBL30128694 | 0.90 | KDR (1.00) | KDRMETNTRK1TEKNTRK2 | |
| Altiratinib SCHEMBL139906 | 0.90 | KDR (1.00) | KDRMETNTRK1TEKNTRK2 | |
| Altiratinib SCHEMBL29358783 | 0.90 | KDR (1.00) | KDRMETNTRK1TEKNTRK2 | |
| SCHEMBL142079 | 0.88 | KDR (0.93) | KDRMETNTRK1TEKNTRK2 | |
| SCHEMBL145837 | 0.86 | KDR (0.87) | KDRMETNTRK1TEKNTRK2 | |
| SCHEMBL143823 | 0.86 | MET (0.78) | KDRMETNTRK1TEKNTRK2 | |
| SCHEMBL142812 | 0.86 | MET (0.77) | KDRMETNTRK1TEKNTRK2 | |
| SCHEMBL138396 | 0.85 | MET (0.82) | KDRMETNTRK1TEKNTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563362-A1 | CYCLOPROPYL DICARBOXAMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITES | Deciphera Pharmaceuticals, LLC (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011137342-A1 | CYCLOPROPYL DICARBOXAMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-11-03 | — | — | WO | disclosed |