Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Altiratinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 19/20 | 1.00 |
| ▸ | MET known ✓ | P08581 | 5/20 | 1.00 |
| ▸ | NTRK1 known ✓ | P04629 | 2/20 | 1.00 |
| ▸ | TEK known ✓ | Q02763 | 1/20 | 1.00 |
| ▸ | NTRK3 known ✓ | Q16288 | 1/20 | 1.00 |
| ▸ | NTRK2 known ✓ | Q16620 | 1/20 | 1.00 |
| ▸ | BRAF | P15056 | 9/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Altiratinib SCHEMBL29358783 | 1.00 | KDR (1.00) | KDRMETNTRK1TEKNTRK3 | |
| Altiratinib SCHEMBL139906 | 1.00 | KDR (1.00) | KDRMETNTRK1TEKNTRK3 | |
| Altiratinib SCHEMBL30128694 | 1.00 | KDR (1.00) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL142079 | 0.96 | KDR (0.93) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL145837 | 0.93 | KDR (0.87) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL138396 | 0.90 | MET (0.82) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL2592755 | 0.90 | KDR (0.81) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL141721 | 0.90 | MET (0.81) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL143639 | 0.88 | MET (0.78) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL143823 | 0.88 | MET (0.78) | KDRMETNTRK1TEKNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4412621-A2 | COMPOSITIONS AND METHODS FOR ENHANCED PROTEIN PRODUCTION | HDT Bio Corp. (US) | 2024-08-14 | — | — | EP | claimed |
| WO-2023056202-A2 | COMPOSITIONS AND METHODS FOR ENHANCED PROTEIN PRODUCTION | HDT BIO CORP. (US) | 2023-04-06 | — | — | WO | claimed |
| EP-4412621-A2 | COMPOSITIONS AND METHODS FOR ENHANCED PROTEIN PRODUCTION | HDT Bio Corp. (US) | 2024-08-14 | — | — | EP | disclosed |
| WO-2023056202-A2 | COMPOSITIONS AND METHODS FOR ENHANCED PROTEIN PRODUCTION | HDT BIO CORP. (US) | 2023-04-06 | — | — | WO | disclosed |