Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.33 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25927872 | 0.93 | JAK2 (0.38) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25931287 | 0.93 | JAK2 (0.42) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25929408 | 0.93 | JAK2 (0.36) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25929255 | 0.93 | EGFR (0.36) | JAK1METAXLMERTKPIK3CA | |
| SCHEMBL25929520 | 0.92 | JAK2 (0.36) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25927636 | 0.89 | JAK2 (0.35) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25932391 | 0.89 | ADK (0.37) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25932661 | 0.89 | ABL1 (0.38) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25929121 | 0.89 | JAK2 (0.42) | JAK2ABL1JAK1TYK2JAK3 | |
| SCHEMBL25929508 | 0.86 | JAK2 (0.37) | JAK2ABL1JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |