Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 18/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.79 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.77 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.77 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.58 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.57 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21475438 | 1.00 | PIM1 (0.79) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL19987100 | 0.89 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL102865 | 0.88 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL136162 | 0.88 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL14639168 | 0.87 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL14639167 | 0.87 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL16211202 | 0.87 | PIM1 (0.79) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL24736843 | 0.87 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL19987067 | 0.87 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2CDK2 | |
| Nuvisertib SCHEMBL19986953 | 0.87 | PIM1 (1.00) | PIM1KCNH2PIM3PIM2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233557-A1 | FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS | SUMITOMO PHARMA ONCOLOGY, INC. (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233557-A1 | FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS | PIM1, GK, PIM2 | PIM1 1/4885KCNH2 1459/4885PIM3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.