Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231117 | 0.84 | HPGD (0.41) | KCNJ1KCNH2MEN1ALDH1A1POLB | |
| SCHEMBL25929324 | 0.81 | CNR1 (0.38) | KCNJ1KCNH2MEN1ALDH1A1POLB | |
| SCHEMBL19254702 | 0.77 | CYP2A6 (0.44) | KCNJ1KCNH2MEN1ALDH1A1POLB | |
| SCHEMBL7658751 | 0.76 | KMT2A (0.36) | KCNJ1KCNH2MEN1ALDH1A1POLB | |
| SCHEMBL1606027 | 0.76 | ALDH1A1 (0.39) | KCNJ1KCNH2MEN1ALDH1A1POLB | |
| SCHEMBL7087447 | 0.68 | KMT2A (0.45) | MEN1ALDH1A1POLBKMT2A | |
| SCHEMBL16954607 | 0.68 | ALDH1A1 (0.40) | MEN1ALDH1A1POLBKMT2ATSHR | |
| SCHEMBL28826019 | 0.67 | HSD17B10 (0.53) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL16954604 | 0.66 | KMT2A (0.39) | MEN1ALDH1A1POLBKMT2ATSHR | |
| SCHEMBL1017722 | 0.66 | MEN1 (0.47) | MEN1ALDH1A1POLBKMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |