Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25931896 | 0.84 | EGFR (0.36) | AXLMERTKEGFRFGFR1FGFR2 | |
| SCHEMBL25927872 | 0.84 | JAK2 (0.38) | AXLMERTKEGFRMETMAP3K7 | |
| SCHEMBL25929685 | 0.83 | MET (0.34) | AXLMERTKEGFRFGFR1FGFR2 | |
| SCHEMBL25932088 | 0.83 | PIK3CD (0.38) | AXLMERTKEGFRFGFR1FGFR2 | |
| SCHEMBL25930865 | 0.83 | MET (0.36) | AXLMERTKEGFRFGFR1FGFR2 | |
| SCHEMBL25931674 | 0.83 | EGFR (0.41) | AXLMERTKEGFRFGFR1FGFR2 | |
| SCHEMBL25932040 | 0.83 | MCHR1 (0.40) | AXLMERTKEGFRFGFR1FGFR2 | |
| SCHEMBL25931226 | 0.82 | LRRK2 (0.35) | AXLMERTKEGFRMETMAP3K7 | |
| SCHEMBL25923430 | 0.80 | MAPK1 (0.42) | AXLMERTKEGFRFGFR1FGFR2 | |
| SCHEMBL25924724 | 0.80 | MET (0.38) | AXLMERTKEGFRGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |