Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 8/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 8/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25925229 | 0.91 | EGFR (0.39) | METMAP3K7TAB1AXLMERTK | |
| SCHEMBL25925739 | 0.88 | MET (0.37) | METMAP3K7TAB1AXLMERTK | |
| SCHEMBL25924810 | 0.86 | MET (0.40) | METMAP3K7TAB1AXLMERTK | |
| SCHEMBL25924720 | 0.86 | CYP1A2 (0.48) | METMAP3K7TAB1MAP4K1MAP4K3 | |
| SCHEMBL25931674 | 0.84 | EGFR (0.41) | METMAP3K7TAB1AXLMERTK | |
| SCHEMBL25924718 | 0.83 | TNK2 (0.49) | METMAP3K7TAB1HTR6EGFR | |
| SCHEMBL25932661 | 0.83 | ABL1 (0.38) | METMAP3K7TAB1GSK3BDYRK1A | |
| SCHEMBL25932391 | 0.82 | ADK (0.37) | METAXLMERTKJAK1 | |
| SCHEMBL25932460 | 0.81 | ALDH1A1 (0.37) | METMAP3K7TAB1AXLMERTK | |
| SCHEMBL2283400 | 0.81 | PDPK1 (0.42) | HTR6GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |