Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15337702 | 0.83 | ALDH1A1 (0.64) | NPC1ALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL10274470 | 0.82 | NPC1 (0.74) | NPC1ALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL14417848 | 0.82 | NPC1 (0.74) | NPC1ALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL15224251 | 0.80 | NPC1 (0.71) | NPC1ALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL13673411 | 0.79 | L3MBTL3 (0.49) | NPC1ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13673413 | 0.79 | NPC1 (0.46) | NPC1ALDH1A1KMT2AMEN1ATM | |
| SCHEMBL15071468 | 0.78 | POLB (0.57) | NPC1ALDH1A1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL14417832 | 0.78 | NPC1 (0.81) | NPC1ALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL14174867 | 0.78 | NPC1 (0.69) | NPC1ALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL9062091 | 0.78 | NPC1 (0.81) | NPC1ALDH1A1RAB9ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242548-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242548-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | KRAS, HRAS, NRAS | NPC1 2113/4885ALDH1A1 2792/4885RAB9A 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.