Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25933234 | 0.82 | NR1H2 (0.43) | PARP1 | |
| SCHEMBL30493266 | 0.82 | NR1H2 (0.43) | PARP1 | |
| SCHEMBL6887543 | 0.80 | KDM4E (0.44) | KCNH2SIRT1ALDH1A1KDM4EHPGD | |
| SCHEMBL25933195 | 0.72 | NR1H2 (0.44) | PARP1 | |
| SCHEMBL25933193 | 0.72 | NR1H2 (0.44) | PARP1 | |
| SCHEMBL30493388 | 0.72 | NR1H2 (0.44) | PARP1 | |
| SCHEMBL30493256 | 0.72 | CHRNA4 (0.39) | CHRNA7 | |
| SCHEMBL25556995 | 0.72 | KCNH2 (0.43) | KCNH2CHRNA7JAK1CDK4CCND1 | |
| SCHEMBL20231703 | 0.70 | NR1H2 (0.42) | — | |
| SCHEMBL22652078 | 0.70 | HSD11B1 (0.40) | KCNH2CHRNA7CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139199-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2023-07-27 | — | — | WO | disclosed |