Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 5/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29390613 | 0.81 | KDM4E (0.45) | — | |
| SCHEMBL25932939 | 0.80 | NR1H2 (0.43) | — | |
| SCHEMBL31243899 | 0.77 | KHK (0.36) | CHRNA4CHRNB2BPTFCHRNB4CHRNA3 | |
| SCHEMBL20120995 | 0.76 | HTR6 (0.46) | — | |
| SCHEMBL20214003 | 0.75 | SIRT6 (0.43) | — | |
| SCHEMBL21876628 | 0.74 | OPRK1 (0.39) | — | |
| SCHEMBL25329310 | 0.73 | OPRK1 (0.39) | — | |
| SCHEMBL25933205 | 0.72 | KCNH2 (0.37) | CHRNA7 | |
| SCHEMBL29389971 | 0.71 | MAPT (0.49) | — | |
| SCHEMBL20120639 | 0.71 | MAPT (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466260-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2024-11-27 | — | — | EP | disclosed |
| WO-2023139199-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2023-07-27 | — | — | WO | disclosed |