SCHEMBL25934018

SCHEMBL25934018

COCc1csc(C2(C)CCOCC2)n1

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 16/20 0.43
F2 P00734 1/20 0.33
ALOX5 P09917 1/20 0.33
CNR1 P21554 3/20 0.33
CNR2 P34972 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25933403 0.84 F2RL3 (0.44) F2RL3F2ALOX5
SCHEMBL15349009 0.82 F2RL3 (0.36) F2RL3ALOX5CNR1CNR2
SCHEMBL15349111 0.70 F2RL3 (0.42) F2RL3F2ALOX5CNR1CNR2
SCHEMBL15349023 0.70 F2RL3 (0.41) F2RL3F2ALOX5CNR1CNR2
SCHEMBL24035816 0.69 L3MBTL1 (0.40) CNR1CNR2
SCHEMBL15348862 0.69 ALOX5 (0.42) F2RL3F2ALOX5CNR1CNR2
SCHEMBL23901916 0.67
SCHEMBL15349260 0.65 F2RL3 (0.36) F2RL3CNR1CNR2
SCHEMBL15349162 0.65 ALOX5 (0.40) F2RL3F2ALOX5CNR1CNR2
SCHEMBL21962502 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242535-A1 IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION BRISTOL MYERS SQUIBB CO (US) 2023-08-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242535-A1 IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION F2RL3, F2R, TMPRSS4 F2RL3 1/4885F2 13/4885ALOX5 1679/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.