Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.50 |
| ▸ | CLK1 | P49759 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 5/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | CDK8 | P49336 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25933932 | 0.92 | DYRK1A (0.50) | CLK4DYRK1ACLK1CDK2CLK2 | |
| SCHEMBL24137530 | 0.86 | FGFR1 (0.56) | CLK4DYRK1ACLK1CDK2FGFR1 | |
| SCHEMBL24137529 | 0.82 | FGFR1 (0.60) | CLK4DYRK1ACLK1CDK2FGFR1 | |
| SCHEMBL24137563 | 0.77 | CCNC (0.61) | CLK4DYRK1ACLK1CDK2FGFR1 | |
| SCHEMBL25934164 | 0.74 | FYN (0.45) | DYRK1ACLK1MAP4K4NTRK1FYN | |
| SCHEMBL24137467 | 0.74 | KCNH2 (0.49) | CLK4DYRK1ACDK2CLK2AURKB | |
| SCHEMBL24137561 | 0.73 | ROCK2 (0.63) | CLK4DYRK1ACLK1CDK2FGFR1 | |
| SCHEMBL25938463 | 0.71 | BRAF (0.45) | DYRK1ACLK1FGFR1NTRK1FYN | |
| SCHEMBL24137567 | 0.70 | DYRK1A (0.56) | CLK4DYRK1ACLK1CDK2FGFR1 | |
| SCHEMBL22191838 | 0.69 | CCNT1 (0.48) | CLK4DYRK1ACLK1CDK2CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234935-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234935-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | PACSIN2, MAP3K20, PHKG1 | CLK4 176/4885DYRK1A 495/4885CLK1 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.