Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670689 | 0.84 | CRBN (0.44) | CRBNDDB1POLBGSPT1 | |
| SCHEMBL30475476 | 0.84 | CRBN (0.41) | CRBNDDB1POLBGSPT1 | |
| SCHEMBL25035106 | 0.84 | CRBN (0.41) | CRBNDDB1POLBGSPT1 | |
| SCHEMBL25448699 | 0.83 | CRBN (0.47) | CRBNDDB1POLBGSPT1 | |
| SCHEMBL30475505 | 0.83 | CRBN (0.48) | CRBNDDB1POLBPDE3BPDE3A | |
| SCHEMBL25823256 | 0.83 | CRBN (0.48) | CRBNDDB1POLBPDE3BPDE3A | |
| SCHEMBL30475503 | 0.82 | CRBN (0.49) | CRBNDDB1POLB | |
| SCHEMBL25822215 | 0.82 | CRBN (0.49) | CRBNDDB1POLB | |
| SCHEMBL25031309 | 0.82 | CRBN (0.43) | CRBNDDB1POLBGSPT1 | |
| SCHEMBL29744915 | 0.82 | CRBN (0.41) | CRBNDDB1POLBGSPT1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-08-03 | — | — | US | disclosed |
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-08-03 | — | — | US | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | CRBN 2136/4885DDB1 132/4885POLB 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.