Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.60 |
| ▸ | RAD52 | P43351 | 7/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 5/20 | 0.59 |
| ▸ | ACHE | P22303 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2583768 | 0.89 | RAD52 (0.71) | SLC2A1RAD52MAPK1TSHRLMNA | |
| SCHEMBL12176124 | 0.87 | KMT2A (0.65) | SLC2A1RAD52MAPK1TSHRLMNA | |
| SCHEMBL2592385 | 0.86 | RAD52 (0.60) | SLC2A1RAD52MAPK1LMNABCHE | |
| SCHEMBL2592170 | 0.83 | SLC2A1 (0.69) | SLC2A1RAD52MAPK1TSHRLMNA | |
| SCHEMBL2583400 | 0.80 | SLC2A1 (0.61) | SLC2A1RAD52MAPK1TSHRLMNA | |
| SCHEMBL12175940 | 0.78 | SLC2A1 (0.70) | SLC2A1RAD52MAPK1TSHRLMNA | |
| SCHEMBL2590485 | 0.78 | MAPT (0.71) | SLC2A1RAD52MAPK1LMNABCHE | |
| SCHEMBL2590855 | 0.78 | RAD52 (0.82) | RAD52MAPK1LMNABCHEACHE | |
| SCHEMBL2583780 | 0.78 | PDE5A (0.67) | SLC2A1RAD52MAPK1TSHRLMNA | |
| SCHEMBL30691665 | 0.77 | HDAC8 (0.59) | MAPK1TSHRLMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |