Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494500 | 0.87 | NR4A2 (0.51) | NR4A2LMNAGAACNR1L3MBTL1 | |
| SCHEMBL2586397 | 0.86 | MCL1 (0.41) | NR4A2LMNAL3MBTL1MAPTKMT2A | |
| SCHEMBL13824516 | 0.86 | NR4A2 (0.67) | NR4A2LMNAGAACNR1L3MBTL1 | |
| SCHEMBL15999018 | 0.81 | NR4A2 (0.52) | NR4A2LMNAGAACNR1L3MBTL1 | |
| SCHEMBL15987501 | 0.81 | GAA (0.53) | NR4A2LMNAGAACNR1L3MBTL1 | |
| SCHEMBL1586664 | 0.81 | NR4A2 (0.52) | NR4A2LMNAGAACNR1L3MBTL1 | |
| SCHEMBL1586684 | 0.81 | GCGR (0.51) | NR4A2LMNAGAACNR1L3MBTL1 | |
| SCHEMBL2590967 | 0.80 | CNR2 (0.45) | CNR1L3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL2038160 | 0.80 | CNR2 (0.53) | NR4A2LMNAGAACNR1L3MBTL1 | |
| SCHEMBL701030 | 0.78 | NR4A2 (0.53) | NR4A2LMNAGAACNR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563774-B1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LTD (CN) | 2014-03-12 | — | — | EP | disclosed |
| US-8501166-B2 | Pyrimidinyl indole compounds | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-08-06 | — | — | US | disclosed |
| US-20130058892-A1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-03-07 | — | — | US | disclosed |
| EP-2563774-A1 | PYRIMIDINYL INDOLE COMPOUNDS | Hutchison Medipharma Limited (CN) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134140-A1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130058892-A1 | PYRIMIDINYL INDOLE COMPOUNDS | NFKBIA, JAK2, IRF3 | NR4A2 824/4885LMNA 4435/4885GAA 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.