Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593643 | 0.80 | NR4A2 (0.53) | CNR1HSD17B10MEN1KMT2AL3MBTL1 | |
| SCHEMBL2586397 | 0.80 | MCL1 (0.41) | CNR2ALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL30808103 | 0.71 | HTR2C (0.55) | KDM4E | |
| SCHEMBL28800286 | 0.70 | HTR2C (0.40) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL2589087 | 0.69 | CRHR1 (0.39) | CNR2ALDH1A1CNR1KDM4EHSD17B10 | |
| SCHEMBL7494500 | 0.68 | NR4A2 (0.51) | CNR2CNR1L3MBTL1TSHR | |
| SCHEMBL3142772 | 0.68 | CNR1 (0.48) | CNR2ALDH1A1CNR1P2RX7 | |
| SCHEMBL25219444 | 0.68 | RAB9A (0.46) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL10598552 | 0.67 | CNR2 (0.63) | CNR2ALDH1A1CNR1 | |
| SCHEMBL3139209 | 0.67 | NR4A2 (0.49) | CNR2ALDH1A1CNR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563774-B1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LTD (CN) | 2014-03-12 | — | — | EP | disclosed |
| US-8501166-B2 | Pyrimidinyl indole compounds | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-08-06 | — | — | US | disclosed |
| US-20130058892-A1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-03-07 | — | — | US | disclosed |
| EP-2563774-A1 | PYRIMIDINYL INDOLE COMPOUNDS | Hutchison Medipharma Limited (CN) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134140-A1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130058892-A1 | PYRIMIDINYL INDOLE COMPOUNDS | NFKBIA, JAK2, IRF3 | CNR2 999/4885ALDH1A1 1943/4885CNR1 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.