Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593643 | 0.86 | NR4A2 (0.53) | POLBL3MBTL1NR4A2LMNAMAPT | |
| SCHEMBL5761906 | 0.83 | CYP19A1 (0.51) | MCL1BADL3MBTL1NR4A2KDM4E | |
| SCHEMBL30285593 | 0.83 | NPC1 (0.41) | MCL1BADLMNAALDH1A1MAPT | |
| SCHEMBL7013723 | 0.81 | POLB (0.58) | POLBL3MBTL1KDM4ELMNAALDH1A1 | |
| SCHEMBL2590967 | 0.80 | CNR2 (0.45) | L3MBTL1KDM4EALDH1A1KMT2ACNR2 | |
| SCHEMBL30808103 | 0.79 | HTR2C (0.55) | NR4A2KDM4ELMNA | |
| SCHEMBL1587389 | 0.78 | TSPO (0.50) | LMNAPLK1ALDH1A1MAPTKMT2A | |
| SCHEMBL28800286 | 0.78 | HTR2C (0.40) | MCL1KDM4EALDH1A1 | |
| SCHEMBL2035893 | 0.77 | CNR2 (0.54) | MCL1BADL3MBTL1ALDH1A1MAPT | |
| SCHEMBL28178378 | 0.77 | CNR2 (0.56) | MCL1BADCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102858764-B | Pyrimidinyl indole compounds | HUTCHISON MEDIPHARMA SHANGHAI LTD | 2014-08-20 | — | — | CN | disclosed |
| EP-2563774-B1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LTD (CN) | 2014-03-12 | — | — | EP | disclosed |
| US-8501166-B2 | Pyrimidinyl indole compounds | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-08-06 | — | — | US | disclosed |
| US-20130058892-A1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-03-07 | — | — | US | disclosed |
| EP-2563774-A1 | PYRIMIDINYL INDOLE COMPOUNDS | Hutchison Medipharma Limited (CN) | 2013-03-06 | — | — | EP | disclosed |
| CN-102858764-A | Pyrimidinyl indole compounds | HUTCHISON MEDIPHARMA SHANGHAI LTD | 2013-01-02 | — | — | CN | disclosed |
| WO-2011134140-A1 | PYRIMIDINYL INDOLE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130058892-A1 | PYRIMIDINYL INDOLE COMPOUNDS | NFKBIA, JAK2, IRF3 | MCL1 256/4885BAD 590/4885POLB 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.