SCHEMBL25936731

SCHEMBL25936731

FCC(F)(F)c1ccc(C2CCNCC2)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 7/20 0.44
SLC6A2 P23975 10/20 0.41
SLC6A4 P31645 10/20 0.41
SLC6A3 Q01959 9/20 0.41
HTR6 P50406 2/20 0.40
HTR1A P08908 6/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25145783 0.84 HTR2C (0.59) HTR2CSLC6A2SLC6A4SLC6A3HTR6
Hydrochloric Acid SCHEMBL4884777 0.83 HTR2C (0.60) HTR2CSLC6A2SLC6A4SLC6A3HTR6
SCHEMBL1037291 0.78 CHRNB2 (0.44) HTR2CSLC6A2SLC6A4SLC6A3HTR6
SCHEMBL31136567 0.76 HTR2A (0.56) HTR2CSLC6A4
SCHEMBL30232333 0.74 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3HTR6HTR1A
SCHEMBL187795 0.74 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3HTR6HTR1A
SCHEMBL25085586 0.74 HTR6 (0.51) HTR2CSLC6A2SLC6A4SLC6A3HTR6
Hydrochloric Acid SCHEMBL2801750 0.73 SLC6A2 (0.54) HTR2CSLC6A2SLC6A4SLC6A3HTR6
SCHEMBL15591909 0.72 CHRNB2 (0.49) HTR2C
SCHEMBL24310183 0.71 USP7 (0.52) HTR2CSLC6A2SLC6A4SLC6A3HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023144160-A1 NEW HETEROCYCLIC COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2023-08-03 WO disclosed