Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.39 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.39 |
| ▸ | CACNA2D4 | Q7Z3S7 | 1/20 | 0.39 |
| ▸ | CACNA2D3 | Q8IZS8 | 1/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937285 | 0.88 | RORC (0.39) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL25937251 | 0.82 | BTK (0.44) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL23889027 | 0.77 | ROCK2 (0.42) | PDE4BPARP1ROCK2 | |
| SCHEMBL30101667 | 0.77 | KDM1A (0.42) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL24011177 | 0.74 | EPHX2 (0.42) | EPHX2KDM1AMAOBKMT2AL3MBTL1 | |
| SCHEMBL25938932 | 0.72 | KDM1A (0.44) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL30101551 | 0.72 | KDM1A (0.38) | CACNA1BPDE4BEPHX2KDM1AMAOB | |
| SCHEMBL25937339 | 0.72 | KDM1A (0.38) | CACNA1BPDE4BEPHX2KDM1AMAOB | |
| SCHEMBL24622426 | 0.72 | KDM1A (0.42) | EPHX2KDM1AMAOBKMT2AL3MBTL1 | |
| SCHEMBL30634806 | 0.72 | PIK3CD (0.40) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230310423-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. | 2023-10-05 | — | — | US | disclosed |
| US-11707462-B2 | Checkpoint kinase 1 (CHK1) inhibitors and uses thereof | BOUNDLESS BIO, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230310423-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | CHEK1, CHEK2, RAD1 | CACNA1B 4816/4885CACNB4 4539/4885CACNA1A 4875/4885 |
| US-11707462-B2 | Checkpoint kinase 1 (CHK1) inhibitors and uses thereof | CHEK1, CHEK2, RAD1 | CACNA1B 4816/4885CACNB4 4539/4885CACNA1A 4875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.