Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25939739 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1LMNA | |
| SCHEMBL25938366 | 0.76 | NPC1 (0.41) | IP6K1MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL25937721 | 0.76 | IKZF2 (0.44) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL25937859 | 0.75 | PTGS1 (0.51) | IP6K1MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL20220042 | 0.74 | GFER (0.42) | MAPTNPC1RAB9APTGS1PTGS2 | |
| SCHEMBL8167269 | 0.74 | ALOX15 (0.44) | IP6K1MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL17048401 | 0.73 | PTGS1 (0.55) | MAPTKMT2AKDM4EMEN1APAF1 | |
| SCHEMBL25999271 | 0.72 | CHEK2 (0.36) | KMT2ANPC1RAB9A | |
| SCHEMBL25938007 | 0.72 | CXCR4 (0.39) | KDM4EALDH1A1HSD17B10TDP1NPC1 | |
| SCHEMBL25944238 | 0.70 | PARP14 (0.37) | MAPTKMT2AMEN1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820574-B1 | 3-(5-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |