Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937737 | 0.82 | TAS1R3 (0.41) | PTGS1PTGS2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL25938708 | 0.77 | IKZF2 (0.42) | PTGS1PTGS2KMT2A | |
| SCHEMBL18417805 | 0.76 | TDP1 (0.38) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL25937646 | 0.75 | IP6K1 (0.44) | PTGS1PTGS2CNR2NPC1RAB9A | |
| SCHEMBL20220042 | 0.75 | GFER (0.42) | PTGS1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL8167269 | 0.75 | ALOX15 (0.44) | PTGS1PTGS2CNR2NPC1RAB9A | |
| SCHEMBL2963191 | 0.74 | PTGS1 (0.43) | PTGS1PTGS2CNR2NPC1RAB9A | |
| SCHEMBL25938366 | 0.74 | NPC1 (0.41) | PTGS1PTGS2CNR2NPC1RAB9A | |
| SCHEMBL23933923 | 0.74 | ALDH1A1 (0.36) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL17048401 | 0.74 | PTGS1 (0.55) | PTGS1PTGS2CNR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820574-B1 | 3-(5-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |