Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | PPM1D | O15297 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143218 | 0.87 | SMN1; SMN2 (0.33) | USP2SMN1; SMN2PPM1DCHRM2CHRM1 | |
| SCHEMBL15512775 | 0.87 | SMN1; SMN2 (0.33) | USP2SMN1; SMN2PPM1DCHRM2CHRM1 | |
| SCHEMBL2121652 | 0.83 | PPM1D (0.32) | USP2SMN1; SMN2PPM1DCHRM2CHRM1 | |
| SCHEMBL29882268 | 0.78 | RORC (0.39) | USP2SMN1; SMN2NR1H2PPM1DRORC | |
| SCHEMBL31105174 | 0.76 | PPM1D (0.36) | USP2SMN1; SMN2NR1H2PPM1D | |
| SCHEMBL29069175 | 0.76 | PPM1D (0.36) | USP2SMN1; SMN2NR1H2PPM1D | |
| SCHEMBL377199 | 0.76 | PPM1D (0.36) | USP2SMN1; SMN2NR1H2PPM1D | |
| SCHEMBL29039966 | 0.76 | PPM1D (0.36) | USP2SMN1; SMN2NR1H2PPM1D | |
| SCHEMBL29039969 | 0.76 | PPM1D (0.36) | USP2SMN1; SMN2NR1H2PPM1D | |
| SCHEMBL142968 | 0.76 | PPM1D (0.36) | USP2SMN1; SMN2NR1H2PPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137022-A1 | AZAINDOLES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-03 | — | — | WO | disclosed |