Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588301 | 0.88 | PDE4D (0.45) | PDE4DKDM4ELMNAMAOBALDH1A1 | |
| SCHEMBL2584001 | 0.84 | PDE4D (0.41) | PDE4DKDM4ELMNAMAOBALDH1A1 | |
| SCHEMBL14735825 | 0.84 | HDAC4 (0.42) | PDE4DKDM4ELMNAMAOBALDH1A1 | |
| SCHEMBL14734816 | 0.83 | ALDH1A1 (0.58) | PDE4DKDM4EALDH1A1HPGDHDAC4 | |
| SCHEMBL14734794 | 0.83 | HPGD (0.45) | PDE4DKDM4ELMNAMAOBALDH1A1 | |
| SCHEMBL17599605 | 0.83 | PDE4D (0.45) | PDE4DKDM4ELMNAMAOBALDH1A1 | |
| SCHEMBL2591613 | 0.82 | MAOB (0.39) | PDE4DKDM4ELMNAMAOB | |
| SCHEMBL2583912 | 0.82 | HDAC4 (0.41) | PDE4DKDM4ELMNAMAOBALDH1A1 | |
| SCHEMBL14737971 | 0.81 | KMT2A (0.40) | PDE4DKDM4ELMNAMAOBALDH1A1 | |
| SCHEMBL2588602 | 0.81 | CLK4 (0.40) | KDM4EALDH1A1HPGDHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |