SCHEMBL259399

SCHEMBL259399

CN(C)Cc1c[nH]c2cccc([N+](=O)[O-])c12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 5/20 0.58
HTR2C P28335 5/20 0.58
HTR2B P41595 5/20 0.58
KDM4E B2RXH2 2/20 0.53
ALDH1A1 P00352 2/20 0.53
MEN1 O00255 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
TSHR P16473 1/20 0.53
CYP2C19 P33261 1/20 0.53
KMT2A Q03164 1/20 0.53
HSD17B10 Q99714 1/20 0.53
CDK2 P24941 1/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
BACE1 P56817 1/20 0.43
HTR6 P50406 2/20 0.43
HTR1A P08908 2/20 0.43
DRD1 P21728 1/20 0.43
HTR1D P28221 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12627931 0.81 CDK2 (0.47) HTR2AKDM4EALDH1A1MEN1CYP3A4
SCHEMBL28770654 0.81 CDK2 (0.46) KDM4EALDH1A1MEN1KMT2ACDK2
SCHEMBL20120186 0.78 HTR2A (0.59) HTR2AHTR2CKDM4EALDH1A1CYP3A4
SCHEMBL260846 0.77 DNA2 (0.49) KDM4EALDH1A1MEN1CYP3A4CYP2D6
SCHEMBL2884596 0.77 ALDH1A1 (0.62) KDM4EALDH1A1MEN1TSHRKMT2A
SCHEMBL261401 0.77 CDK2 (0.44) KDM4EALDH1A1MEN1KMT2ACDK2
SCHEMBL30799165 0.77 DNA2 (0.49) KDM4EALDH1A1MEN1CYP3A4CYP2D6
SCHEMBL260104 0.77 ALDH1A1 (0.56) KDM4EALDH1A1MEN1KMT2ACDK2
Iodide SCHEMBL5650891 0.76 DNA2 (0.48) KDM4EALDH1A1MEN1CYP3A4CYP2D6
SCHEMBL20119875 0.76 KDM4E (0.58) KDM4EALDH1A1MEN1KMT2ACDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3284680-A None JP disclosed
EP-1951042-B1 SPIROLACTAM TRICYCLIC CGRP RECEPTOR ANTAGONISTS MERCK SHARP & DOHME (US) 2012-10-10 EP disclosed
EP-1951051-B1 SPIROHYDANTOIN TRICYCLIC CGRP RECEPTOR ANTAGONISTS MERCK SHARP & DOHME (US) 2012-10-03 EP disclosed
US-8163752-B2 Tricyclic anilide heterocyclic CGRP receptor antagonists Merck, Sharp & Dohme Corp. (US) 2012-04-24 US disclosed
US-8163752-B2 Tricyclic anilide heterocyclic CGRP receptor antagonists Merck, Sharp & Dohme Corp. (US) 2012-04-24 US disclosed
US-8133891-B2 Tricyclic anilide spirolactam CGRP receptor antagonists Merck, Sharp & Dohme Corp. (US) 2012-03-13 US disclosed
US-8133891-B2 Tricyclic anilide spirolactam CGRP receptor antagonists Merck, Sharp & Dohme Corp. (US) 2012-03-13 US disclosed
CN-101076527-B Tricyclic anilide spirohydantoin cgrp receptor antagonists MERCK SHARP & DOHME CORP. (US) 2011-11-30 CN disclosed
EP-1794146-B1 TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS MERCK SHARP & DOHME (US) 2011-08-03 EP disclosed
US-7968540-B2 Spirohydantoin tricyclic CGRP receptor antagonists MERCK SHARP & DOHME CORP. (US) 2011-06-28 US disclosed
US-5891870-A ANTIINFLAMMATORY AGENTS USING BENZODITERPENES AND BENZOLACTAMS PROCYON PHARMACEUTICALS, INC. (US) 1999-04-06 US disclosed
US-5886017-A Protein kinase C modulators. E. PROCYON PHARMACEUTICALS, INC. (US) 1999-03-23 US disclosed
US-5886019-A REPLACEMENT OF HYDROXYMETHYL OR-ETHYL GROUP ON TRICYCLIC AROMATIC HETEROCYCLIC COMPOUNDS HAVING INDOLE, INDENE, BENZOFURAN OR BENZOTHIOPHENE SKELETON; ANTIINFLAMMATORY, ANTIVIRAL PROCYON PHARMACEUTICALS, INC. (US) 1999-03-23 US disclosed
US-5750568-A DITERPENE PHORBOIDS PROCYON PHARMACEUTICALS, INC. (US) 1998-05-12 US disclosed
US-5716968-A ANTIINFLAMMATORY AGENTS; VIRICIDE PROCYON PHARMACEUTICALS, INC. (US) 1998-02-10 US disclosed
US-5643948-A ANTIINFLAMMATORY, ANTICANCER PROCYON PHARMACEUTICALS, INC. (US) 1997-07-01 US disclosed
EP-0553107-A1 PROTEIN KINASE C MODULATORS WITH ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY PROCYON PHARMACEUTICALS, INC. (US) 1993-08-04 EP disclosed
US-5145842-A Protein kinase c. modulators. d. ALDER RESEARCH CENTER LIMITED PARTNERSHIP (US) 1992-09-08 US disclosed
WO-1992002484-A1 PROTEIN KINASE C MODULATORS WITH ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY ALDER RESEARCH CENTER LIMITED PARTNERSHIP (US) 1992-02-20 WO disclosed
JP-H03284680-A IMMUNOSUPPRESSIVE AGENT SNOW BRAND MILK PROD CO LTD 1991-12-16 JP disclosed