Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25940602 | 0.87 | TDP1 (0.48) | MAPTTDP1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL20487896 | 0.87 | MAPT (0.42) | MAPTTDP1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL25925436 | 0.83 | GAA (0.40) | MAPTALDH1A1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL12480283 | 0.83 | MAPT (0.48) | MAPTTDP1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL29854924 | 0.78 | MAPT (0.43) | MAPTTDP1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL20488622 | 0.78 | MAPT (0.43) | MAPTTDP1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL20489035 | 0.76 | TDP1 (0.44) | MAPTTDP1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL12480120 | 0.75 | LMNA (0.43) | MAPTTDP1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL25925420 | 0.73 | MAPT (0.43) | MAPTALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL22349631 | 0.73 | TDP1 (0.54) | MAPTTDP1L3MBTL1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718626-B2 | Macrocyclic compounds for treatment of medical disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718626-B2 | Macrocyclic compounds for treatment of medical disorders | CFD, TFPI, CFH | MAPT 3729/4885TDP1 4701/4885L3MBTL1 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.