Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20676287 | 0.84 | KMO (0.60) | KMONPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL13726783 | 0.83 | KMO (0.48) | HTR2AHTR2CKMONPC1RAB9A | |
| SCHEMBL22357880 | 0.81 | NPC1 (0.58) | HTR2AHTR2CKMONPC1RAB9A | |
| SCHEMBL2589000 | 0.80 | RAB9A (0.62) | KMONPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL27165381 | 0.78 | BRD4 (0.55) | HTR2AHTR2CKMOLMNANPC1 | |
| SCHEMBL655869 | 0.76 | SYK (0.59) | — | |
| SCHEMBL29520619 | 0.76 | HTR2A (0.65) | HTR2AHTR2CKMOTSHRBRD4 | |
| SCHEMBL13727580 | 0.75 | CHEK1 (0.54) | HTR2AHTR2CKMONPC1RAB9A | |
| SCHEMBL3346151 | 0.74 | RAB9A (0.39) | KMONPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30816458 | 0.73 | HTR2A (0.57) | HTR2AHTR2CKMOSCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | claimed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |