SCHEMBL25945446

SCHEMBL25945446

C=C(C)C(=C)Oc1ccc(-c2ccc(-c3ccc(OC(=O)C(=C)C)c(OC)c3)cc2F)cc1OC(=O)C(=C)C

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AMY1A P0DUB6 1/20 0.39
PTGS2 P35354 5/20 0.38
ERN1 O75460 2/20 0.38
APP P05067 1/20 0.37
CYP2C19 P33261 1/20 0.37
AKR1C3 P42330 1/20 0.37
AKR1C2 P52895 1/20 0.37
ABCB1 P08183 1/20 0.37
AR P10275 1/20 0.37
MAPT P10636 1/20 0.36
TDP2 O95551 1/20 0.36
FFAR1 O14842 1/20 0.35
PRKCZ Q05513 1/20 0.35
CTSA P10619 1/20 0.35
GAPDH P04406 1/20 0.35
PTGS1 P23219 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24440894 0.95 AMY1A (0.41) AMY1APTGS2ERN1APPCYP2C19
SCHEMBL18699583 0.93 AR (0.42) AMY1APTGS2ERN1APPCYP2C19
SCHEMBL26144314 0.91 ERN1 (0.42) AMY1APTGS2ERN1ARMAPT
SCHEMBL26144313 0.91 ERN1 (0.42) AMY1APTGS2ERN1ARMAPT
SCHEMBL25944835 0.90 ERN1 (0.43) AMY1APTGS2ERN1ABCB1AR
SCHEMBL15338821 0.90 GAPDH (0.41) ERN1APPCYP2C19AKR1C3AKR1C2
SCHEMBL25944828 0.89 ERN1 (0.45) AMY1APTGS2ERN1APPCYP2C19
SCHEMBL15338898 0.89 GAPDH (0.40) ERN1APPCYP2C19AKR1C3AKR1C2
SCHEMBL25933764 0.87 FGFR1 (0.40) AMY1APTGS2ERN1AKR1C3AKR1C2
SCHEMBL26144316 0.87 ERN1 (0.44) AMY1APTGS2ERN1APPCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4056667-B1 LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS MERCK PATENT GMBH (DE) 2023-08-02 EP disclosed