Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.40 |
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15471727 | 0.82 | KDM4E (0.56) | KDM4EPARP10PARP1PARP11F7 | |
| SCHEMBL31510260 | 0.81 | KDM4E (0.45) | KDM4EMAPTALDH1A1PARP10PARP1 | |
| SCHEMBL28899149 | 0.78 | ALDH1A1 (0.66) | KDM4EMAPTALDH1A1PARP10PARP1 | |
| SCHEMBL27087781 | 0.78 | KDM4E (0.45) | KDM4EMAPTALDH1A1PARP10PARP1 | |
| SCHEMBL17064696 | 0.78 | PARP10 (0.50) | KDM4EMAPTALDH1A1PARP10PARP1 | |
| SCHEMBL18875036 | 0.78 | PARP10 (0.50) | KDM4EMAPTALDH1A1PARP10PARP1 | |
| SCHEMBL27087811 | 0.78 | PARP10 (0.50) | KDM4EHTR2BMAPTALDH1A1PARP10 | |
| SCHEMBL15471844 | 0.77 | PARP10 (0.51) | KDM4EPARP10PARP1PARP11F7 | |
| SCHEMBL2205282 | 0.75 | MEN1 (0.48) | KDM4EMAPTALDH1A1PARP10PARP1 | |
| SCHEMBL26670926 | 0.75 | PARP10 (0.43) | KDM4ECYP1A2MAPTALDH1A1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALITY S.A. (CH) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | MAP4K1, MAP3K4, MAP4K2 | KDM4E 1939/4885CYP1A2 2895/4885CYP2D6 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.