Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 12/20 | 0.58 |
| ▸ | CDK2 | P24941 | 4/20 | 0.58 |
| ▸ | CDK7 | P50613 | 8/20 | 0.56 |
| ▸ | CCNH | P51946 | 8/20 | 0.56 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
| ▸ | MELK | Q14680 | 2/20 | 0.47 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25947621 | 0.91 | PAK4 (0.60) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL22924067 | 0.90 | PAK4 (0.61) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL29658878 | 0.88 | PAK4 (0.56) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL22924083 | 0.86 | CDK7 (0.72) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL28738721 | 0.86 | CDK7 (0.72) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL28738717 | 0.83 | P2RY14 (0.41) | CDK7CCNHMNAT1NTRK1 | |
| SCHEMBL17878632 | 0.83 | PAK4 (0.58) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL20741127 | 0.82 | CDK7 (0.58) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL20741131 | 0.82 | CDK7 (0.58) | PAK4CDK2CDK7CCNHMNAT1 | |
| SCHEMBL17872161 | 0.82 | CDK7 (0.58) | PAK4CDK2CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242534-A9 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-08-03 | — | — | US | disclosed |
| US-20230242534-A9 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-08-03 | — | — | US | disclosed |
| EP-4003335-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242534-A9 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF | CDK2, CDK5, CDK9 | PAK4 469/4885CDK2 1/4885CDK7 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.