Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31304006 | 0.88 | DHFR (0.50) | DHFRDCPSMAP4K1MAPK14KDM4E | |
| SCHEMBL21684178 | 0.88 | DHFR (0.50) | DHFRDCPSMAP4K1MAPK14KDM4E | |
| SCHEMBL21684767 | 0.84 | ALDH1A1 (0.47) | DHFRDCPSMAP4K1MAPK14MEN1 | |
| SCHEMBL21702983 | 0.83 | MAPK14 (0.44) | MAP4K1MAPK14PSEN1PSEN2APH1B | |
| SCHEMBL25947417 | 0.81 | MAPK14 (0.43) | MAP4K1MAPK14PSEN1PSEN2APH1B | |
| SCHEMBL21684882 | 0.78 | MAPK14 (0.47) | DHFRDCPSMAP4K1MAPK14 | |
| SCHEMBL21683581 | 0.78 | MAP4K1 (0.66) | MAP4K1 | |
| SCHEMBL21683584 | 0.78 | MAP4K1 (0.66) | MAP4K1 | |
| SCHEMBL28581797 | 0.77 | MAP4K1 (0.59) | MAP4K1 | |
| SCHEMBL31450621 | 0.77 | MAP4K1 (0.59) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |