Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 16/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25947829 | 0.89 | MAP4K1 (0.51) | MAP4K1HTTMAPTPKMPOLB | |
| SCHEMBL21703319 | 0.84 | MAP4K1 (0.54) | MAP4K1 | |
| SCHEMBL25947504 | 0.84 | MAP4K1 (0.61) | MAP4K1 | |
| SCHEMBL21683830 | 0.83 | MAP4K1 (0.81) | MAP4K1 | |
| SCHEMBL21683827 | 0.83 | MAP4K1 (0.81) | MAP4K1 | |
| SCHEMBL21703184 | 0.82 | MAP4K1 (0.72) | MAP4K1 | |
| SCHEMBL25947469 | 0.82 | MAP4K1 (0.74) | MAP4K1 | |
| SCHEMBL25947430 | 0.79 | MAP4K1 (0.58) | MAP4K1 | |
| SCHEMBL25947664 | 0.79 | MAP4K1 (0.57) | MAP4K1 | |
| SCHEMBL21703000 | 0.79 | MAP4K1 (1.00) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |