Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | TEC | P42680 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25331964 | 0.87 | POLB (0.45) | POLBPDE10AKMT2AMEN1NPC1 | |
| SCHEMBL18412836 | 0.76 | TRPV3 (0.39) | PDE10A | |
| SCHEMBL15057161 | 0.75 | POLB (0.49) | POLBPDE10AKMT2AKDM4E | |
| SCHEMBL18412776 | 0.72 | POLB (0.36) | POLBPDE10AGLSKMT2AMEN1 | |
| SCHEMBL15058026 | 0.71 | POLB (0.42) | POLBPDE10AKMT2AMEN1NPC1 | |
| SCHEMBL25332852 | 0.71 | POLB (0.42) | POLBPDE10AKMT2AMEN1RAB9A | |
| SCHEMBL25333467 | 0.71 | POLB (0.42) | POLBPDE10AKMT2AKDM4E | |
| SCHEMBL24680127 | 0.70 | POLB (0.41) | POLBPDE10AKMT2AKDM4E | |
| SCHEMBL21816284 | 0.70 | GABRP (0.53) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL15058465 | 0.70 | NPSR1 (0.42) | POLBPDE10ANPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133271-A1 | BICYCLIC PHTHALAZIN-1(2H)-ONE DERIVATIVES AND RELATED USES | NodThera Limited (GB) | 2023-07-13 | — | — | WO | disclosed |