Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | POLB | P06746 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 4/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594616 | 0.78 | HCRTR1 (0.83) | MAPTPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL2596036 | 0.76 | POLB (0.73) | MAPTPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL2461656 | 0.72 | ALDH1A1 (0.63) | MAPTALDH1A1HTTL3MBTL1TSHR | |
| Hydrochloric Acid SCHEMBL5969836 | 0.71 | ALDH1A1 (0.62) | MAPTALDH1A1HTTL3MBTL1TSHR | |
| SCHEMBL2591711 | 0.71 | HCRTR1 (0.74) | MAPTPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL2592900 | 0.70 | HCRTR1 (1.00) | MAPTPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL2594555 | 0.70 | HCRTR1 (0.67) | MAPTPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL2592990 | 0.69 | POLB (0.74) | MAPTPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL2588313 | 0.69 | HCRTR1 (0.76) | MAPTPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL7709772 | 0.69 | HCRTR1 (1.00) | MAPTPOLBMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | claimed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |