Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 1.00 |
| ▸ | HCRTR2 | O43614 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 11/20 | 0.81 |
| ▸ | MAPT | P10636 | 10/20 | 0.81 |
| ▸ | THRB | P10828 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594616 | 0.91 | HCRTR1 (0.83) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL2588313 | 0.86 | HCRTR1 (0.76) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL2591711 | 0.85 | HCRTR1 (0.74) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL2592510 | 0.81 | L3MBTL1 (0.70) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL2592644 | 0.81 | HCRTR1 (0.70) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL7707718 | 0.80 | HCRTR1 (1.00) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL7711063 | 0.78 | HCRTR1 (0.96) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL2594733 | 0.78 | HCRTR1 (0.96) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL2596036 | 0.77 | POLB (0.73) | HCRTR1HCRTR2POLBMAPTTHRB | |
| SCHEMBL27249973 | 0.74 | L3MBTL1 (1.00) | HCRTR1HCRTR2POLBMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |