Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20571761 | 0.76 | PSMB5 (0.49) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL21672469 | 0.76 | KDM4E (0.30) | MAPTKDM4EALDH1A1LMNATP53 | |
| Hydrochloric Acid SCHEMBL30529512 | 0.74 | PSMB5 (0.48) | MAPTKDM4EALDH1A1LMNATP53 | |
| SCHEMBL19031641 | 0.72 | MAPT (0.44) | MAPTALDH1A1GAATDP1CA9 | |
| SCHEMBL7420610 | 0.68 | GRIA1 (0.39) | MAPTKDM4EALDH1A1LMNATP53 | |
| SCHEMBL25949532 | 0.68 | MAPT (0.33) | HRH3MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL7420662 | 0.67 | MAPT (0.44) | HRH3MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL7496406 | 0.67 | ACHE (0.39) | KDM4EALDH1A1LMNAHTTDRD2 | |
| SCHEMBL15569945 | 0.67 | PLK1 (0.44) | HRH3UHRF1 | |
| SCHEMBL13326543 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555070-B1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2023-08-09 | — | — | EP | disclosed |