Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416358 | 0.90 | NOTUM (0.41) | HTR2AHTR2CDRD2DHFRKDM4E | |
| Hydrochloric Acid SCHEMBL7416277 | 0.89 | NOTUM (0.40) | HTR2AHTR2CDHFRKDM4EMAPT | |
| SCHEMBL20571761 | 0.75 | PSMB5 (0.49) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| Hydrochloric Acid SCHEMBL30529512 | 0.73 | PSMB5 (0.48) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| SCHEMBL28379476 | 0.73 | DRD2 (0.41) | HTR2AHTR2CDRD2HTR1A | |
| SCHEMBL28384798 | 0.73 | KDM4E (0.38) | HTR2AHTR2CDHFRKDM4EMAPT | |
| SCHEMBL4929162 | 0.72 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| SCHEMBL9919049 | 0.70 | GAA (0.38) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| SCHEMBL25949654 | 0.68 | HRH3 (0.33) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| SCHEMBL12068243 | 0.68 | UHRF1 (0.36) | GRIA1GRIA2GRIA3GRIA4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |