Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595324 | 0.82 | RIPK2 (0.38) | PDE4BPIK3CDALOX5APFEN1RIPK2 | |
| SCHEMBL8371819 | 0.78 | IKBKB (0.48) | PDE4BPIK3CDIKBKBALOX5APFEN1 | |
| SCHEMBL2594418 | 0.77 | PIK3CA (0.41) | FEN1 | |
| SCHEMBL2595613 | 0.76 | RIPK2 (0.35) | PIK3CDALOX5APFEN1RIPK2KDR | |
| SCHEMBL2595583 | 0.76 | RIPK2 (0.36) | PDE4BPIK3CDALOX5APFEN1RIPK2 | |
| SCHEMBL2588243 | 0.74 | RIPK3 (0.39) | ALOX5APFEN1RIPK2KDRRIPK3 | |
| SCHEMBL2588246 | 0.71 | RIPK3 (0.36) | RIPK2KDRRIPK3RIPK1TGFBR1 | |
| SCHEMBL14718384 | 0.71 | RIPK2 (0.76) | PDE4BPIK3CDIKBKBRIPK2KDR | |
| SCHEMBL2595034 | 0.69 | RIPK3 (0.34) | RIPK2RIPK3RIPK1GCK | |
| SCHEMBL2585625 | 0.67 | RIPK3 (0.35) | RIPK2KDRRIPK3RIPK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |