Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.41 |
| ▸ | AKT1 | P31749 | 11/20 | 0.41 |
| ▸ | MTOR | P42345 | 6/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595324 | 0.90 | RIPK2 (0.38) | FEN1 | |
| SCHEMBL2595613 | 0.82 | RIPK2 (0.35) | FEN1 | |
| SCHEMBL2585288 | 0.78 | CD38 (0.33) | — | |
| SCHEMBL2595020 | 0.77 | PDE4B (0.50) | FEN1 | |
| SCHEMBL2595291 | 0.76 | RIPK3 (0.34) | PIK3CAMTORATMATR | |
| SCHEMBL14717191 | 0.75 | RIPK2 (0.66) | PIK3CA | |
| SCHEMBL14717733 | 0.70 | RIPK2 (0.64) | PIK3CA | |
| SCHEMBL14717804 | 0.70 | RIPK2 (0.64) | PIK3CA | |
| SCHEMBL14718741 | 0.70 | RIPK2 (0.64) | PIK3CA | |
| SCHEMBL2595583 | 0.70 | RIPK2 (0.36) | FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |