Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595324 | 0.84 | RIPK2 (0.38) | RIPK2KDRRIPK1RIPK3GCK | |
| SCHEMBL2594418 | 0.82 | PIK3CA (0.41) | FEN1 | |
| SCHEMBL14717972 | 0.76 | RIPK2 (0.66) | RIPK2KDRRIPK1RIPK3CHRM5 | |
| SCHEMBL2595020 | 0.76 | PDE4B (0.50) | RIPK2KDRRIPK1RIPK3GCK | |
| SCHEMBL2595291 | 0.71 | RIPK3 (0.34) | RIPK2RIPK1RIPK3MCL1 | |
| SCHEMBL2595583 | 0.71 | RIPK2 (0.36) | RIPK2KDRRIPK1RIPK3GCK | |
| SCHEMBL2588243 | 0.70 | RIPK3 (0.39) | RIPK2KDRRIPK1RIPK3ALOX5AP | |
| SCHEMBL2585288 | 0.70 | CD38 (0.33) | RIPK2RIPK1RIPK3MCL1 | |
| SCHEMBL12180812 | 0.68 | TXNRD1 (0.38) | RIPK2KDRTXNRD1 | |
| SCHEMBL2595034 | 0.68 | RIPK3 (0.34) | RIPK2RIPK1RIPK3GCKMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |