Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 14/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 8/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892553 | 0.89 | PRMT5 (0.35) | PRMT5WDR77METTL3ACACBPIP4K2A | |
| SCHEMBL18571793 | 0.83 | PRMT5 (0.50) | PRMT5WDR77METTL3 | |
| SCHEMBL23892429 | 0.83 | PRMT5 (0.50) | PRMT5WDR77METTL3 | |
| SCHEMBL22002119 | 0.81 | PRMT5 (0.40) | PRMT5WDR77METTL3 | |
| SCHEMBL23892507 | 0.76 | NPC1 (0.36) | PRMT5WDR77ACACBPIP4K2A | |
| SCHEMBL23892478 | 0.75 | METTL3 (0.37) | PRMT5WDR77METTL3 | |
| SCHEMBL18572901 | 0.75 | METTL3 (0.32) | PRMT5METTL3 | |
| SCHEMBL22002300 | 0.74 | PRMT5 (0.45) | PRMT5WDR77METTL3 | |
| SCHEMBL23892679 | 0.74 | PRMT5 (0.45) | PRMT5WDR77METTL3 | |
| SCHEMBL23892590 | 0.74 | PRMT5 (0.42) | PRMT5WDR77METTL3PIP4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |