Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595054 | 0.84 | DYRK1A (0.40) | DYRK1AGCKPIK3CDALOX5APFEN1 | |
| SCHEMBL2248217 | 0.70 | MEN1 (0.46) | CYP2C9CYP3A4CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL17044042 | 0.65 | DYRK1A (0.45) | DYRK1APIK3CDATMATRKLK3 | |
| SCHEMBL14698006 | 0.65 | CYP2C9 (0.42) | CYP2C9CYP3A4CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL2594415 | 0.62 | CYP2C9 (0.42) | CYP2C9CYP3A4CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL28048555 | 0.62 | DYRK1A (0.72) | DYRK1APIK3CDCLK1CLK2CLK3 | |
| SCHEMBL3575522 | 0.61 | ALDH1A1 (0.49) | DYRK1AGCKPIK3CDMEN1ALDH1A1 | |
| SCHEMBL5729056 | 0.61 | DYRK1A (0.46) | DYRK1APIK3CDMEN1ALDH1A1GAA | |
| SCHEMBL2595324 | 0.61 | RIPK2 (0.38) | GCKPIK3CDALOX5APFEN1RIPK2 | |
| SCHEMBL14537176 | 0.60 | MAP4K4 (0.47) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |