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Sugi Predict / Compounds / SCHEMBL25951122

SCHEMBL25951122

SCHEMBL25951122

CC(C)(C)OC(=O)N(c1ncnc2c1ccn2[C@@H]1O[C@H](COc2ccc3ccc(NCc4ccccc4)nc3c2)[C@H]2OC(C)(C)O[C@H]21)C(O)OC(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 9/20 0.43
▸ PRMT5 O14744 15/20 0.42
▸ WDR77 Q9BQA1 9/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18571909 0.92 METTL3 (0.47) METTL3PRMT5WDR77
SCHEMBL22684565 0.85 PRMT5 (0.38) METTL3PRMT5WDR77
SCHEMBL18571915 0.82 PRMT5 (0.48) METTL3PRMT5WDR77
SCHEMBL18571615 0.78 PRMT5 (0.52) METTL3PRMT5WDR77
SCHEMBL18572602 0.78 PRMT5 (0.45) METTL3PRMT5WDR77
SCHEMBL18571912 0.78 PRMT5 (0.40) METTL3PRMT5WDR77
SCHEMBL25951059 0.78 PRMT5 (0.32) PRMT5WDR77
SCHEMBL18571616 0.78 PRMT5 (0.50) METTL3PRMT5WDR77
SCHEMBL25949268 0.77 PRMT5 (0.34) PRMT5WDR77
SCHEMBL18572006 0.77 PRMT5 (0.42) METTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219496-A1 NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS JANSSEN Pharmaceutica NV (BE) 2023-08-02 — — EP disclosed
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