Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595538 | 1.00 | HSD17B10 (0.48) | HSD17B10GAAUSP2ALDH1A1TSHR | |
| SCHEMBL2583252 | 0.81 | ADORA1 (0.46) | HSD17B10GAAUSP2ALDH1A1RAB9A | |
| SCHEMBL2583255 | 0.81 | ADORA1 (0.46) | HSD17B10GAAUSP2ALDH1A1RAB9A | |
| SCHEMBL16104433 | 0.80 | TMIGD3 (0.44) | HSD17B10ALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL2589672 | 0.78 | MAPT (0.42) | HSD17B10GAAUSP2ALDH1A1TSHR | |
| SCHEMBL2589678 | 0.78 | MAPT (0.42) | HSD17B10GAAUSP2ALDH1A1TSHR | |
| SCHEMBL14149184 | 0.76 | GPR88 (0.44) | HSD17B10GAAUSP2ALDH1A1TSHR | |
| SCHEMBL2588353 | 0.76 | RAB9A (0.50) | HSD17B10ALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL14060102 | 0.76 | GPR88 (0.44) | HSD17B10GAAUSP2ALDH1A1TSHR | |
| SCHEMBL2588355 | 0.76 | RAB9A (0.50) | HSD17B10ALDH1A1RAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569319-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141396-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-17 | — | — | WO | disclosed |